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5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (DMB) 1

agglomeration 1

agitation rate 1

antiviral properties 1

benzimidazole 1

coxsackie virus B₃ 1

crystallization temperature 1

feeding rate 1

reactive crystallization 1

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Control of the agglomeration of crystals in the reactive crystallization of 5-(difluoromethoxy)-2-mercapto-1

Yongli WANG, Shuyuan MA, Xiaodong Lü, Chuang XIE

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 4, Pages 423-431 doi: 10.1007/s11705-012-1211-7

Abstract: 5-(Difluoromethoxy)-2-mercapto-1 -benzimidazole (DMB) was precipitated by adding acetic acid to the DMBThe spherical agglomeration of DMB during the reactive crystallization in a batch crystallizer was monitoredBy using a simple model, the mean crystal agglomerate size of DMB thus predicted is generally in agreementIn addition, the crystallization process of DMB was optimized by a new control strategy of supersaturation

Keywords： 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (DMB) reactive crystallization agglomeration